Case Study (CNEM)

Over 96% reduction in enrolment timelines for metabolic disorder study.

A meta-analysis of 28 studies demonstrated that higher serum 25(OH)D levels were associated with a 55% reduction in diabetes, a 51% decreased risk of the metabolic syndrome and a 33% lower risk of cardiovascular disease (Strange et al., 2015). CNEM’s team assessed serum 25(OH)D intervention in individuals with obesity.

The Challenge

CNEM required a dedicated patient cohort to commit to 12-14 site visits across 4 months. Neucruit was able to provide a site-external patient registry of men and women with BMI >25 between 25-60 that fulfilled CNEM’s eligibility criteria to take part in their 12-week randomised controlled trial.

A high volume of site visits negatively impacted recruitment due to the amount of patient time investment required for participation. In addition, the requirement for in-person site visits led to delays during the pandemic.

Site-based recruitment during the pandemic was extremely difficult. Further, visits to primary care facilities was also limited during the pandemic making recruitment more difficult. A substantial number of patients were not able to attend regular check-ups. It’s estimated that over 90% of primary care visits were missed between 2020 and 2021.

This meant that site-external recruitment was required for the study.

The Solution

Our team began by conducting an audit of the existing recruitment system, creating a clear understanding of the access points for patients. In this process, the full patient journey was mapped assessing design, spacing and user flow. At each step, we helped the client understand where outreach would be optimised in recruitment moving forwards.

After gaining critical insight into the existing infrastructure, Neucruit’s data mapping algorithm was deployed to build key hypotheses around ideal patient profiles in Bath, United Kingdom – within 15 miles of the site radius. This included mapping demographics, interests and delocalisation of motivated individuals for the study. Alongside this, micro-site variations were built with pre-screening functionality and tested in region-specific patient populations.

Hypotheses were validated using a set of campaigns. Campaign data was collected and utilised in a feedback process, using real-time optimisation to improve the recruitment framework and patient profiles accessed. Once a dominant framework was established, the team monitored the platform for the client until full delivery.

Statistics

Demographics by region

Platform
Participants
Percentage
Facebook
121
55%
Instagram
55
25%
Google
30
15%
Twitter
2
1%
Reddit
1
1%
Pinterest
1
1%
0%

Reduction in site staff time requirements

0%

Increase in enrolment rate

0%

Reduction in enrolment timelines

Our efforts resulted in:

96%

Reduction in enrollement timeline

50

Participants randomized

2.9

Months saved

The Result

Neucruit was able to provide a site-external patient registry of men and women with BMI >25 between 25-60 that fulfilled CNEM’s eligibility criteria to take part in their 12-week randomised controlled trial.

A great platform for participant recruitment. They are great at following up and notifying us of other potential participant groups. Our working relationship has been flawless and the RAMP team would highly recommend using them as a route for recruiting participants into your study.

-Dr. Young

I think the team are very easy to work with and friendly! I would recommend them if you have tight recruitment deadlines.

-Ms. Sun

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