Case Study (RAMP)

670% increase in black minority ethnic participation in anxiety and depression study.

RAMP was a nation-wide study assessing longitudinal impact in mood disorders through the collection of real-time data on patient’s physiological, emotional, cognitive, and motor activities. The objective of RAMP was to monitor the impact of isolation in individuals suffering from anxiety and depression as well as the incidence of mood disorders in healthy volunteer populations in correlation with extended isolation.

The Challenge

RAMP garnered substantial interest in the UK population with over 10,000 participants within the first 6 months of recruitment. However, demographic data demonstrated that of the 10,000 participants enrolled into the study, only 62 individuals identified as black. This equated to a proportion of 0.6% of the study population – whereas, the proportion of black individuals in the UK population was ~3%.

Without proportionate representation, the team could not make any valid comparisons between groups, as in scientific terms, our research would lack statistical power. In order to evaluate data that was proportionally representative of the UK population, a minimum of 300 participants identifying as black needed to be enrolled into the study.

Historically, over 96% of clinical studies have taken place in white populations. Substantial barriers exist preventing individuals from black minority ethnic (BME) groups from accessing and participating in clinical research.

The Solution

Our team began by conducting an audit of the existing recruitment system, creating a clear understanding of the access points for BME patients. In this process, the full patient journey was mapped assessing language and flow from one patient audience to another. At each step, we helped the client understand where accessibility would be optimised in recruitment moving forwards.

After gaining critical insight into the existing infrastructure, Neucruit’s data mapping algorithm was deployed to build key hypotheses around ideal BME patient profiles within the United Kingdom. This included mapping demographics, interests and delocalisation of motivated BME individuals for the study. Alongside this, micro-site variations were built with pre-screening functionality and tested in BME patient populations.

Hypotheses were validated using a set of campaigns. Campaign data was collected and utilised in a feedback process, using real-time optimisation to improve the recruitment framework and patient profiles accessed. Once a dominant framework was established, the team monitored the platform for the client until full delivery.

Statistics

Demographics by region

Platform
Participants
Percentage
Instagram
451
32%
Twitter
392
28%
Google
315
22%
Facebook
121
9%
Pinterest
85
6%
Reddit
18
1%
0%

Increase in BME enrolment rate

0%

Increase in BME study representation

0%

Reduction in recruitment timelines for BME population

Our efforts resulted in:

769%

Increase in BME enrolment rate

231

BME randomizations

17

Months saved

The Result

The client was able to reach their BME participation target in 3 months as compared to the original 20 month estimation based on their historical enrolment rate, reducing timelines by 85%. Further, valuable information was generated regarding target audiences and ideal BME patient profiles in anxiety and depression studies.

Quick and effortless: a very reliable source for collecting data for our study. The set-up is quick and effortless, something that us researchers need more and more. I would definitely recommend them.

-Dr. V. Sideropoulos

Collecting participants is always a daunting process. Neucruit made the process feasible. I’m very happy with the friendly customer service and effort from the team. Thank you!

-B. Masala

Ready to improve accessibility for your patient audiences?

Speak to a member of our team today to transform the way patients are made aware of cutting-edge clinical research and products by combining data, AI and modern media. 

Case Study (CNEM)

Over 96% reduction in enrolment timelines for metabolic disorder study.

A meta-analysis of 28 studies demonstrated that higher serum 25(OH)D levels were associated with a 55% reduction in diabetes, a 51% decreased risk of the metabolic syndrome and a 33% lower risk of cardiovascular disease (Strange et al., 2015). CNEM’s team assessed serum 25(OH)D intervention in individuals with obesity.

The Challenge

CNEM required a dedicated patient cohort to commit to 12-14 site visits across 4 months. Neucruit was able to provide a site-external patient registry of men and women with BMI >25 between 25-60 that fulfilled CNEM’s eligibility criteria to take part in their 12-week randomised controlled trial.

A high volume of site visits negatively impacted recruitment due to the amount of patient time investment required for participation. In addition, the requirement for in-person site visits led to delays during the pandemic.

Site-based recruitment during the pandemic was extremely difficult. Further, visits to primary care facilities was also limited during the pandemic making recruitment more difficult. A substantial number of patients were not able to attend regular check-ups. It’s estimated that over 90% of primary care visits were missed between 2020 and 2021.

This meant that site-external recruitment was required for the study.

The Solution

Our team began by conducting an audit of the existing recruitment system, creating a clear understanding of the access points for patients. In this process, the full patient journey was mapped assessing design, spacing and user flow. At each step, we helped the client understand where outreach would be optimised in recruitment moving forwards.

After gaining critical insight into the existing infrastructure, Neucruit’s data mapping algorithm was deployed to build key hypotheses around ideal patient profiles in Bath, United Kingdom – within 15 miles of the site radius. This included mapping demographics, interests and delocalisation of motivated individuals for the study. Alongside this, micro-site variations were built with pre-screening functionality and tested in region-specific patient populations.

Hypotheses were validated using a set of campaigns. Campaign data was collected and utilised in a feedback process, using real-time optimisation to improve the recruitment framework and patient profiles accessed. Once a dominant framework was established, the team monitored the platform for the client until full delivery.

Statistics

Demographics by region

Platform
Participants
Percentage
Facebook
121
55%
Instagram
55
25%
Google
30
15%
Twitter
2
1%
Reddit
1
1%
Pinterest
1
1%
0%

Reduction in site staff time requirements

0%

Increase in enrolment rate

0%

Reduction in enrolment timelines

Our efforts resulted in:

96%

Reduction in enrollement timeline

50

Participants randomized

2.9

Months saved

The Result

Neucruit was able to provide a site-external patient registry of men and women with BMI >25 between 25-60 that fulfilled CNEM’s eligibility criteria to take part in their 12-week randomised controlled trial.

A great platform for participant recruitment. They are great at following up and notifying us of other potential participant groups. Our working relationship has been flawless and the RAMP team would highly recommend using them as a route for recruiting participants into your study.

-Dr. Young

I think the team are very easy to work with and friendly! I would recommend them if you have tight recruitment deadlines.

-Ms. Sun

Ready to improve accessibility for your patient audiences?

Speak to a member of our team today to transform the way patients are made aware of cutting-edge clinical research and products by combining data, AI and modern media. 

Case Study (IQOS)

Over 87% reduction in enrolment timelines for smoking cessation study.

IQOS launched in 2014 – this was a device set to transform smoking cessation starting in Japan. At present, there are over 18 million IQOS users globally. The IQOS device is classified as a heat-not-burn technology enabling users to inhale a nicotine-containing vapour through heated rather than burned tobacco.The widely accepted concept amongst users is that since the tobacco doesn’t burn, the levels of harmful chemicals is significantly reduced compared to cigarette smoke (Phillip Morrison, 2022).

The Challenge

This study assessing the health impacts of the IQOS Heat-not-Burn device in 45 participants involved one site visit and had a primary end date of March 2020. This end date was substantially delayed due to the pandemic.

In total, 16 participants were enrolled over the course of 12 months. This averages to approximately 1.3 participants per month at this site. With no intervention, enrolment timelines based on historical data would have modelled complete enrolment in ~22 months.

Beyond the pandemic, several challenges hindered enrolment rates. This included i) the identification of patients that fit temporally stringent eligibility criteria,  ii) complex conversion pathways for patients and iii) coordination of site availability.

The Solution

Our team began by conducting an audit of the existing recruitment system, creating a clear understanding of the conversion points for patients from outreach to randomisation. In this process, the full patient journey was mapped assessing spacing, user design and the flow from one conversion point to another. At each step, we helped the client understand where data would be collected to optimise recruitment moving forwards.

After gaining critical insight into the existing infrastructure, Neucruit’s data mapping algorithm was deployed to build key hypotheses around ideal patient profiles within the study. This included mapping demographics, interests and delocalisation of motivated individuals for the study. Alongside this, micro-site variations were built with pre-screening functionality and tested in select patient populations.

Hypotheses were validated using a set of campaigns. Campaign data was collected and utilised in a feedback process, using real-time optimisation to improve the recruitment framework and patient profiles accessed. Once a dominant framework was established, the team monitored the platform for the client until full delivery.

Statistics

Demographics by region

Platform
Participants
Percentage
Facebook
11
35%
Pinterest
8
25%
Instagram
5
15%
Google
3
10%
Twitter
2
5%
Reddit
1
1%
0%

Enrolment rate per month

0%

Reduction in enrolment timeline

0%

Enrolment targets met

Our efforts resulted in:

769%

Enrolment rate per month

29

Randomizations

19

Months saved

The Result

The client was able to reach their target in 3 months as compared to the original 22 month estimation based on their historical enrolment rate, reducing timelines by over 87%. Further, valuable information was generated regarding target audiences and ideal patient profiles for the IQOS heat-not-burn product.

The team are very responsive and friendly and assisted us with advertising our study to participants with specific demographics and who met our inclusion criteria. Thank you for your help!

-Dr. A. Burton

I highly recommend. An outstanding vehicle to support recruiting for research studies. We’ve needed this support mechanism for a long time.

-Dr. S. Hillman

Ready to improve accessibility for your patient audiences?

Speak to a member of our team today to transform the way patients are made aware of cutting-edge clinical research and products by combining data, AI and modern media. 

Accelerating Research on Vitamin D exposure in Chronic Obesity

Young Health Metabolism Obesity

Accelerating Research on Vitamin D exposure in Chronic Obesity

Costumer

The client is a centre for nutrition, exercise, and metabolism from on of the UK’s top universities

Challenge

Building and retaining a site-external patient registry for a longitudinal study on patients with obesity

Solution

Neucruit provided the clients team with access to a custom site-external patient registry     for obesity

Results

Neucruit facilitated patient recruitment with a 94% reduction in outreach timelines. the Client has strengthened  their   research program

About the client

The client is a nationally recognised team seeking to understand the impact of nutrition and exercise on human physiology and metabolism, ranging from the prevention of chronic diseases such as type 2 diabetes through to the enhancement of training and performance for athletes.

"Using Neucruit facilitated a 94% reduction in outreach timelines"

Using Neucruit to accelerate research 

The clients research group became aware of Neucruit through an academic research training network. One of the online sessions focused on the use of online communities to facilitate site-external patient recruitment.

The clients team began conducting research on vitamin D status on the metabolism of patients with chronic obesity. 

Neucruit was able to provide a site-external patient registry of men and women with BMI >25 between 25-60 that fulfilled the clients eligibility criteria to take part in their 12-week randomised controlled trial.

About Neucruit

Neucruit is a global platform that uses real-time data to help biopharmaceutical companies, site teams, and investigators enhance clinical research planning and delivery through intelligent analytics on the patient journey. Furthermore, Neucruit combines unique patient insights with longitudinal clinical data to optimise site selection patient recruitment and gain insights that can’t be easily accessed through traditional methods. If you want to know more about us and our work, please contact us.

Expediting research assessing the impact of external factors on mood

Covid-19 Flow Test

Expediting research assessing the impact of external factors on mood

Costumer

This client is a child health group and is closely associated with one of Londons top universities

Challenge

Finding a fitting sample for the clients study in a timely and efficient manner

Solution

Neucruit provided the patient recruitment tools to identify potential study participants

Results

Neucruit successfully promoted the study and managed to recruit more than 20 participants fitting the research criteria

About the client

The client is a child mental health research, training and treatment centre located in London, United Kingdom, closely associated with top universities in the UK and US. The Centre aims to transform current mental health provision in the UK by improving the quality, accessibility and effectiveness of treatment, bringing together leaders in neuroscience, mental health, social care and education.

"Neucruit facilitated a timely and efficient recruitment process"

Using Neucruit to accelerate research 

The research group approached  Neucruit with an immediate  need to recruit study participants for their assessment  of how the way a person presents themselves on social media may be linked to their mood.

Neucruit has proven successful in making sure potential participants fitting the criteria were aware of the study, achieving the recruitment of the required number of participants for the study sample to be complete.

Neucruit was able to provide a site-external patient registry of participants across the UK , fulfilling the clients eligibility criteria and increasing participant diversity, including greater BAME populations.

About Neucruit

Neucruit is a global platform that uses real-time data to help biopharmaceutical companies, site teams, and investigators enhance clinical research planning and delivery through intelligent analytics on the patient journey. Furthermore, Neucruit combines unique patient insights with longitudinal clinical data to optimise site selection patient recruitment and gain insights that can’t be easily accessed through traditional methods. If you want to know more about us and our work, please contact us.

Facilitating Longitudinal Data Collection in Mental Health

Facilitating Longitudinal Data Collection in Mental Health​

Costumer

This client is a leading centres for mental health from one of the most prestigious universities      in London

Challenge

Building a site-external patient registry for a longitudinal study on the effects of COVID-19 on mental health

Solution

Neucruit provided the study team with access to a site-external patient registry for people suffering poor         mental health

Results

Building a site-external patient registry for a longitudinal study on the effects of COVID-19 on mental health

About the client

The client is a research institution dedicated to discovering what causes mental illness and diseases of the brain. In addition, its aim is to help identify new treatments for them and ways to prevent them in the first place. The client is a faculty of one of Londons most prestigious universities.

"Using Neucruit ensured a dedicated patient cohort committed to participation in the trial"

Using Neucruit to accelerate research 

Setting up a patient registry to assess the impact of COVID-19 on mental health, using Neucruit, About Neucruit King’s College London the client research group became aware of Neucruit through an academic research training network. One of the online sessions focused on the use of online communities to facilitate site-external patient recruitment. 

Neucruit was able to provide a site-external patient registry of participants across the UK , fulfilling the clients eligibility criteria and increasing participant diversity, including greater BAME populations.

About Neucruit

Neucruit is a global platform that uses real-time data to help biopharmaceutical companies, site teams, and investigators enhance clinical research planning and delivery through intelligent analytics on the patient journey. Furthermore, Neucruit combines unique patient insights with longitudinal clinical data to optimise site selection patient recruitment and gain insights that can’t be easily accessed through traditional methods. If you want to know more about us and our work, please contact us.

Neucruit has been helping rapid lateral flow testing for COVID-19

Neucruit has been helping rapid lateral flow testing for COVID-19

Costumer

This client is an innovative health company making medicine more proactive

Challenge

Finding sufficient patients that were in the specific 2-5 day window of COVID infection

Solution

Neucruit provided the patient recruitment solution, utilising social media to outreach to potential patients

Results

Neucruit recruited all 30 patients with viral COVID-19 (in days 2-5 of symptoms) in 28 days, reducing timelines by 93%

About the client

Our client is a predictive health company focused on making medicine more proactive. They are an innovative UK, and VC backed start-up supported by one of the UK’s top universities.

‘A team of scientists, engineers, and designers solving the world’s most critical healthcare problems.’

" Neucruit facilitated a 93% reduction in outreach timelines"

Using Neucruit to accelerate research 

The clients’ team approached Neucruit after struggling to recruit sufficient participants to test their novel lateral flow test.

Finding these patients and efficiently processing them within their infective period was difficult, also the study organisers had recruited only 5 patients in 48 days. This significantly delayed the validation of their lateral flow tests.

Nevertheless, Neucruit successfully recruited all 30 patients with viral COVID-19 (in days 2-5 of symptoms) within 28 days, reducing timelines by 93%.

About Neucruit

Neucruit is a global platform that uses real-time data to help biopharmaceutical companies, site teams, and investigators enhance clinical research planning and delivery through intelligent analytics on the patient journey. Furthermore, Neucruit combines unique patient insights with longitudinal clinical data to optimise site selection patient recruitment and gain insights that can’t be easily accessed through traditional methods. If you want to know more about us and our work, please contact us.

Neucruit facilitates the study of Alcohol Dependence in Isolation

Neucruit facilitates the study of Alcohol Dependence in Isolation

Costumer

This client is an innovative health company making medicine more proactive.

Challenge

Finding respondents to answer surveys regarding alcohol consumption at different points during  COVID-19 lockdowns

Solution

Neucruit provided the patient recruitment tools to identify potential participants and expedite patient recruitment

Results

Neucruit successfully promoted the study and managed to recruit study participants fitting the research criteria

About the client

The client is a public research group based in the city of Liverpool. It comprises three faculties organised into 35 departments and schools. It is a founding member of the Russell Group and the N8 Group for research collaboration.

"Neucruit supported a timely and efficient recruitment process"​

Using Neucruit to accelerate research 

International and UK data suggested that lockdowns have impacted alcohol consumption. In the UK, alcohol purchasing increased in the weeks prior to the first lockdown (March 2020), suggesting stockpiling behaviour.The research group approached Neucruit to find participants to assess the impact of COVID-19 lockdowns on drinking behaviour.

Soon after being approached by the study coordinator, Neucruit deployed its recruitment acceleration tools and contributed to the recruitment of 539 participants.

About Neucruit

Neucruit is a global platform that uses real-time data to help biopharmaceutical companies, site teams, and investigators enhance clinical research planning and delivery through intelligent analytics on the patient journey. Furthermore, Neucruit combines unique patient insights with longitudinal clinical data to optimise site selection patient recruitment and gain insights that can’t be easily accessed through traditional methods. If you want to know more about us and our work, please contact us.